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      Preclinical work

      Sirolimus + BHT (Butylated Hydroxy Toluol): Persistence in the vessel wall

      • Porcine overstretch model
      • Persistence of sirolimus in the vessel wall: 40% to 50% of the transferred drug until 1 month (SeQuent® SCB)
      • Similar efficacy to reduce intimal hyperplasia as compared to the SeQuent® Please paclitaxel-coated balloon [1]

      Sirolimus + BHT

      • Controlled release of Sirolimus
      • Creation of the desired crystalline sirolimus modification [1]
      Representative histological examples. Top left, Uncoated control; top right, AS. Bottom, from left to right: Vb 4, Vb 7, SeQuent® Please. AS indicates amorphous sirolimus coating; and Vb, crystalline sirolimus coating.

      Drug release and drug persistence in the vessel wall

      Drug transfer (Tissue concentration)

      After 28 days: 40 to 50% of the initial transferred sirolimus dose are still within the arterial wall. [1]

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      [1] Clever et al. Circ Cardiovasc Interv. 2016 Apr;9(4):e003543.

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